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blood-brain barrier (BBB)

johnymax: The BBB is a protective barrier that separates the circulating blood from the brain and spinal cord, limiting the passage of substances from the bloodstream into the CNS. For gene therapy targeting the brain, AAV vectors need to either bypass or cross the BBB to deliver genes to the brain cells. https://www.ebraincase.com/support/literature-interpretation/2394.html

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